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Melinda Gordon (Jennifer Love Hewitt) is a young woman from the town of Grandview, New York, who has the ability to see and communicate with the dead. Melinda lives with her husband, Jim Clancy (David Conrad), and later their son Aiden (Connor Gibbs). She owns a shop called "Same as It Never Was Antiques".
Each ghost seeks Melinda's help in relaying a message or completing a task that will put their spirit to rest, and allow them to cross over into the light. Those who died with unfinished business become earthbound and cannot cross over, and Melinda, as their earthly representative, helps them to find peace. The show does not present the ghosts as having sinned; rather it is the spirits' own guilt that condemns them, and their own fear of judgment that keeps them from "crossing over" into an afterlife.
The series also starred Aisha Tyler as Andrea Marino, Melinda's best friend, who runs the antique shop with her. Andrea is killed in the finale of season 1 when she was driving to her brother's apartment located in the city. During the premiere of season 2, Melinda meets Delia Banks (Camryn Manheim), a struggling real estate agent who forms a friendship with Melinda and who eventually agrees to run the antique shop with her. Delia is a widow. Her husband died prior to the show. Delia is shocked to find out about Melinda's abilities; in fact, at first she claims Melinda needs psychological help. Delia eventually accepts Melinda's gift, though she remains skeptical at times. Delia has a son named Ned Banks (Tyler Patrick Jones and Christoph Sanders) who finds out about Melinda's gift long before his mother does.